Modeling Alpha-Synuclein Ensemble Using Bayesian Weighting Algorithm
نویسندگان
چکیده
منابع مشابه
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations.
The intrinsically disordered protein alpha-synuclein plays a key role in the pathogenesis of Parkinson's disease (PD). We show here that the native state of alpha-synuclein consists of a broad distribution of conformers with an ensemble-averaged hydrodynamic radius significantly smaller than that expected for a random coil structure. This partial condensation is driven by interactions between t...
متن کاملBayesian Shot Detection Using Structural Weighting
A video stream consists of a number of shots each of which has different boundary types such as cut, fade, and dissolve. Many previous approaches can find the cut boundary without difficulty. However, most of them often produce false alarms for the videos with large motions of camera and objects. In this paper, we demonstrate that the shape of the histogram difference between two successive col...
متن کاملDynamic Weighting A* Search-Based MAP Algorithm for Bayesian Networks
In this paper we propose the Dynamic Weighting A* (DWA*) search algorithm for solving MAP problems in Bayesian networks. By exploiting asymmetries in the distribution of MAP variables, the algorithm is able to greatly reduce the search space and offer excellent performance both in terms of accuracy and ef ciency.
متن کاملImproving Predictions Using Ensemble Bayesian Model Averaging
We present ensemble Bayesian model averaging (EBMA) and illustrate its ability to aid scholars in the social sciences to make more accurate forecasts of future events. In essence, EBMA improves prediction by pooling information from multiple forecast models to generate ensemble predictions similar to a weighted average of component forecasts. The weight assigned to each forecast is calibrated v...
متن کاملCalcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
Aggregation of the pre-synaptic protein, α-synuclein (α-syn), is the key etiological factor in Parkinson's disease (PD) and other alpha-synucleinopathies, such as multiple system atrophy (MSA) and Dementia with Lewy bodies (DLB). Various triggers for pathological α-syn aggregation have been elucidated, including post-translational modifications, oxidative stress, and binding of metal ions, such...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.545